On April 5, 1959, the division of Blessed Sacrament Church and the establishment of the Church of the Nativity came to be. At this time, Most Reverend Paul Hallinan was Bishop of Charleston, Reverend Monsignor John J. McCarthy was Pastor of Blessed Sacrament Church and Reverend Theodore T. Cilwick was Pastor of Saint Patrick Church, Charleston. Bishop Hallinan decreed the division of Blessed Sacrament Parish, "in order to provide more adequately for the spiritual welfare of its members."

Father Cilwick was assigned as pastor of the newly formed Church of the Nativity Parish which had approximately 1400 members. The Church of the Nativity was dedicated by Bishop Hallinan on April 10, 1959. The same day, Father Cilwick celebrated the first mass at the Church.

Coinciding with the construction of the church was the creation of a Catholic school with only four classrooms for grades one through four. It opened its door that same day to 160 students from Blessed Sacrament School. The school now has an enrollment of approximately 150 students from kindergarten through grade eight.

During Monsignor Robert J. Kelly's administration, the building of the present church was started. Reverend Joseph. G. Maher celebrated the first mass in the new church on Easter, March 29-30, 1986. 

On January 24, 1998, Bishop David B. Thompson celebrated the Mass of Dedication for the new church building (shown in photo). This was a special occasion for the parish to celebrate its history and to honor the present and former pastors.